Printmaker Leopoldo Morales Praxedis was born in 1953 in Apizaco, Tlaxcala, Mexico. He was an active member of the Taller de Gráfica Popular from 1974 to 1981. As teacher, he was affiliated with the artistic education section of the National Fine Arts Institute, at which he was elected Fellow in 1989.

In 1994 he co-founded the art collective Grupo de Vagoni in Granada with fellow Mexican printmakers Paúl Morales, Ligia Sandino, Adán González, Jairo Orozco, Johnny García, and Javier Tercero. The collective's efforts to promote Mexican printmaking attracted international printmaking masters, including Wolfgang Hunecke, Francisco Álvarez (Spain), Jacinto Lara (Spain), Juán Bernal Ponce, Jesús Nuñez (Spain), Anu Toumisaari (Finland), Gottfried Helnwein (Germany, and many others.

His works are in the collections of the National Institute of Fine Arts (INBA); National Museum of Mexican Art in Chicago; Mexic-Arte Museum of Austin, TX; Institute of Tlaxcala Culture; Autonomous University of Tlaxcala; and the Bancroft Library, University of California, Berkeley.