Constance R. Grace has stated that she has been an artist since she was a child. While holding no official degree in art, she took private art lessons in Okinawa, Japan and also studied at the Smithsonian Institution, the Corcoran School of Art, and the Northern Virginia Community College. After viewing the exhibition Provincetown Printers, A Woodcut Tradition at what is now the Smithsonian American Art Museum, she studied the process with Ruth Hogan at her studio on Cape Cod. Grace began her career as a printmaker and shared a studio at the Torpedo Factory Art Center in Alexandria, Virginia.

Besides creating her artwork, Grace was co-chair of the Original Print Calendar for thirty-four years and president of Printmakers, Inc. at the Torpedo Factory. She was also a member of and served as exhibitions chairperson for the Colored Pencil Society of America. Solo exhibitions of her work were mounted at the Washington Printmakers Gallery, Washington, D.C.; the Torpedo Factory Art Center, Alexandria, Virginia; and the Oarsman Gallery, Bethesda, Maryland.  

The work of Constance R. Grace is in the permanent collections of Georgetown University, the National Museum of Women in the Arts, the Smithsonian American History Museum, and the Smithsonian American Art Museum, Washington, D.C.; and the Museum of Modern Art, Buenos Aires, Argentina.