Aida Anthony Whedon was born Aida Anthony in New Orleans, Louisiana on May 1, 1915 to Mark and Marie Delery Anthony. She moved to the New York to study art at the Art Students League between 1933 and 1938, where she studied with both Regionalist painter Thomas Hart Benton and Abstract Expressionist Hans Hoffman. She also studied printmaking between 1975 and 1980 with Atelier 17 artist Ruth Leaf at the New School of Social Research.

Aida Whedon and her husband, Daniel Clark Whedon (1916-2003), a sculptor, operated the Aida Whedon School of Art in Port Washington, New York, teaching what was been described in her obituary as "thousands of children" and "her New Orleans accent unaltered despite half a century in New York."

She worked as a painter and a printmaker, her etchings were included in exhibitions at the Hecksher Museum, Huntington, NY, 1976, and the Royal Academy Exhibition, Sweden 1977-78. Whedon's works are in many collections, including the North Shore Unitarian Church of Plandome, L.I., the universities of Maine, Chicago and Rutgers, and many banks and corporations. After her first show at the Walker Gallery in New York in 1937, she had one-person shows at the South Street Museum, the Graphic Eye Gallery in Port Washington, and galleries in England, Maine, New York and Long Island.

Aida Anthony Whedon died on April 19, 1994 in Port Washington, New York.