Charles Henry Harmon was born on December 23, 1859 in Mansfield, Ohio. He moved to San Jose, California with his family in 1874 and at an early age was apprenticed to local portrait painter Louis Lussier. He later spent one year working in a local photography studio re-touching negatives. His youth was spent visiting the art galleries of San Francisco and, with no formal training, he began sketching and painting in 1883 in the beautiful Santa Clara Valley. He painted many landscapes of that area and made trips to the remotest parts of the Sierra and the Monterey Peninsula where he painted many coastal scenes. He began exhibiting in San Jose in the 1880s.

By the turn of the century, his works were handled exclusively by Gump's and he was recognized as one of California's foremost painters. In 1905 he established a studio in Denver and for seven years concentrated on the rugged landscape of the Rocky Mountains. While there, the Santa Fe, Western Pacific, and Colorado, Midland railroads commissioned him to paint scenes along their routes. After his time in Colorado, he returned to San Jose where he remained for the rest of his life. Harmon died there on October 14, 1936 and is buried in Oak Hill Cemetery.