This etching was trimmed to small margins (1/8") and the signature is on a tab in the lower right, similar to many of Whistler's works.
Ludgate Hill is the name of a street which runs between St. Paul's Churchyard and Ludgate Circus (built in 1864), from where it becomes Fleet Street. It was formerly a much narrower street called Ludgate Street.
This is a view of the Ludgate Hill from Circus railway bridge. The iron railway bridge took passing trains through to Blackfriars and Holborn. Ludgate Hill station and its approach on New Bridge Street closed to the public in 1929, travellers preferring to use alternative nearby stations. The steeple of Sir Christopher Wren's St. Martin's is in the background, with St. Paul's dome at the left.